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Current Research Studies

: Access to the internet and mobile applications in a mixed population emergency department  »

Principal Investigator(s): Shannon Toohey, MD

Co-Investigator(s): Warren Wiechmann, MD, MBA

EMRAP Liaison(s): Michelle Nguyen

Purpose: To collect follow-up survey responses from patients regarding accessibility to mobile devices, texting, internet access, email and social media such as Facebook and Twitter. We aim to quantify the percentage of our emergency department patients who have access to these resources.

Alcohol risk assessment using computerized alcohol screening instrument in trauma patients (TCASI) »

Principal Investigator: Shahram Lotfipour, MD, MPH

EMRAP Liaison: Jordan Zhang

Purpose: To evaluate the alcohol consumption habits of trauma patients in the Emergency Department.

Association between AUDIT, alcohol and immune biomarkers and liver ultrasound findings (AIBL)  »

Principal Investigator(s): Wirachin Hoonpongsimanont, MD, MS

EMRAP Liaison(s)

Nicholas Gossett, Ishan Shah, Daniel Nasr

Purpose: For this prospective study, we aim to assess correlations between AUDIT scores, serum phosphatidylethanol (PeTH) levels, liver health and patient immune functions. We aim to determine how alcohol affects internal biological systems and identify the cutoff values where human immune function and the liver begin to experience the impact of alcohol use. We will also compare AUDIT scores and PeTH levels (retrieved from patient blood samples) in both trauma and non-trauma adult, ED patients and determine correlations between self-reported alcohol use and serum PeTH levels.

Emergency Medicine Palliative Care Access (EMPallA) »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Calvin Xu

Purpose: To compare nurse-led telephonic case management to facilitated outpatient speciality palliative care in enhancing quality of life and reducing healthcare use, loneliness, and burden on caregivers.

Emergency Department Over-Dispensing of Opioid Pills in Wrist Fracture Patients »

Principal Investigator: Dr. Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Kristi Kim

Purpose: To determine what common opioids are over-dispensed in the emergency department. More specifically, amongst patients with wrist fractures including distal radius, distal ulnar, ulnar styloid, and scaphoid fractures who are discharged with an opioid prescription.

Feasibility of an emergency-department-based food insecurity screening & referral program »

Principal Investigator: Bharath Chakravarthy, MD, MPH

Co-Investigator: Victor Cisneros, MD, MPH

EMRAP Liaison(s): Holly Nguyen, Zaid Parekh


  1. To assess the effectiveness of an emergency-department-based screening and referral to resources for food insecurity.
  2. To quantify and describe the correlation between emergency department visit and food insecurity in Orange County.
How an Educational Program on Emergency Department Expectations Effects Patient Satisfaction (QI Patient Satisfaction)  »

Principal Investigator: Alaina Brinley, MD, PhD

Co-Investigators: Shannon Toohey, MD, Alisa Wray, MD

Emrap Liaison: Michael Sherwood

Purpose: The purpose of this study is to understand if an educational video about ER wait times shown upon arrival to the ER can improve patient satisfaction scores

Incidence of Detecting a Culprit Occlusion on Patients with Percutaneous Coronary Intervention (PCI) Activation Having Regional Wall Motion Abnormalities on Emergency Point of Care Cardiac Ultrasound (STEMI) »

Principal Investigators: Shadi Lahham, MD, MS, Eric Abrams, MD,

EMRAP Liaisons: Monica Desai, George Mina

Purpose:The purpose of this study is to determine if cardiac POCUS can detect RWMA on patients presenting to the emergency department with chest pain meeting STEMI activation criteria. We will evaluate if there is an association between patients who have a regional wall motion abnormality detected on bedside point-of-care ultrasound and their incidence of finding an occlusion on subsequent coronary angiography.

Investigating a Substance Abuse Screening and Brief Intervention in a Trauma Setting (CADSI) »

Principal Investigator(s): Cristobal Barrios, MD, FACS

EMRAP Liaison(s): Rahul Tuli, Jordan Zhang

Purpose: The primary outcome is to identify the population demographics of individuals in a trauma setting who report substance use through a substance abuse screening tool. The secondary outcome is to implement a brief intervention among individuals in the target population that are at moderate to high risk of substance abuse. The tertiary outcome is to analyze this data in order to create a standardized brief intervention tool that can be implemented in a trauma setting to reduce an individual’s level of risk.

Knowledge retention of opioid education in emergency department patients using a multimedia platform »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Jasper Van

Purpose: To measure knowledge retention of opioid analgesics safety through a multimedia presentation for patients who are prescribed opioid analgesics in the adult ED. Having established feasibility in the previous stage, this stage seeks to understand whether or not patients better retain information dispensed through a multimedia platform better than the current standard of care. 

National Emergency Airway Registry (NEAR) »

Principal Investigator: Sangeeta Sakaria, MD, MPH, MST

Co-Investigator(s): Maxwell Jen, MD, MBA & Scott Pierce, MD

EMRAP Liaison(s): Calvin Xu

Purpose: The goal of the study is to collect self-reported data by the  physician pertaining to emergency intubation events such as patient vital signs, physical characteristics that classify the patient as a potential difficult airway, any drugs administered, intubation devices used, the confirmation of intubation success, and number of intubation attempts. Data collected from the UCI Medical Center Emergency Department will be part of a national emergency airway management registry, National Emergency Airway Registry (NEAR). The database allows investigators the ability to examine multi-center intubation practices, as over 30 abstracts and manuscripts have utilized data drawn from NEAR.

Tissue Oxygen Saturation in Necrotizing Soft Tissue Infections as a Diagnostic and Treatment Guide: Emergency Medicine Cohort (NIRS-NSTI) »

Principal Investigator: Sebastian D. Schubl, MD, FACS, Surgery

EMRAP Liaisons: Abdulsattar “Afnan” Mohammed, Isabelle Nepomuceno

Purpose: To assess the use of a new reusable technology provided by Vioptix called Near Infrared Spectroscopy that can measure tissue oxygen tension in order to differentiate regular skin infections/cellulitis from “flesh eating” bacterial infections/necrotizing fasciitis in the critical early stages.

Point-of-Care ultrasound measurement of carotid artery parameters compared to sphygmomanometer blood pressure measurement »

Principal Investigator: Alaina Brinely, MD, PhD

Co-Investigators: John Christian Fox, MD, RMDS and Shadi Lahham, MD

EMRAP Liaison(s): Kristi Kim, Sohrab Kharabaf

Purpose: The purpose of the study is to find blood velocity and compliance of the carotid artery using point-of- care ultrasound, and use these measurements to derive a novel, efficient, and accurate method for obtaining patient blood pressure in an emergency setting.

Point-of-Care ultrasound in the diagnosis of necrotizing fasciitis »

Principal Investigator: Shadi Lahham, MD, MS

Co-Investigator: Inna Shniter, MD

EMRAP Liaison: Monica Desai

Purpose: To determine if ED physicians are able to diagnose NSTI and its corresponding disposition to emergent surgical intervention.

Post-market study of BandGrip in traumatic wound closure compared to suture »

Principal Investigator(s): Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Dylan Cline

Purpose: To determine if BandGrip will be a safe and effective device for temporary wound closure in the Emergency Department by assessing wound closure time, patient discomfort, cosmetic outcome and subject satisfaction compared to standard suture closure.

Using a Linear Probe to Identify Early Pregnancies with Respect to BMI »

Principal Investigator: Shadi Lahham, MD

EMRAP Liaisons: Michelle Thao Nguyen, Isabelle Nepomuceno, Erinna Thai

Purpose: The purpose of this study is to (1) determine whether linear transducer is a reliable tool for evaluation of early pregnancies and (2) identify the BMI ranges at which emergency physicians can quickly identify an early first trimester with a linear probe.